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Sir William Watson (1717–1787) began his scientific career as an apothecary and gained distinction as a botanist. He was elected to the Royal Society in 1741 and appointed a founding trustee of the British Museum. From about 1744, Watson experimented with electricity, becoming a collaborator and ally of Benjamin Franklin. In 1757, he resigned from the Apothecaries Society to pursue a career in medicine. On 12 October 1767, Watson performed his first experiment. Thirty-one children were divided into three groups and inoculated. Ten children (five boys and five girls) received a mixture of mercury and jalap (a laxative) before and after the puncture; 10 children (five of each sex) received an infusion of senna and syrup of roses (a mild laxative) on three occasions and 11 boys received no medicines. Thin ‘watery ichor’ from an early lesion on a patient with natural smallpox was used as the inoculum in all three groups. Watson’s brilliant idea was his method for measuring the effect of inoculation, which allowed him to compare the results in the three groups. [J R Soc Med 2014 Jun;107(6):246–248. doi: 10.1177/0141076814536351]