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The Mechanism of Pancreatic Secretion. (Seventeen Figures in the Text). - [FOUNDING THE SCIENCE OF ENDOCRINOLOGY.]
(London), Journal of Physiology, 1902. Offprint from the Journal of Pysiology. Vol. XXVIII. No. 5, 1902. Pp. (325-) 353, 17 textfigs. Small staples in inner margin, also sewn. A very small stain in lower blank margin.
![The Mechanism of Pancreatic Secretion. (Seventeen Figures in the Text). - [FOUNDING THE SCIENCE OF ENDOCRINOLOGY.]. "BAYLISS, W.M. & E. H. STARLING.](https://static.livre-rare-book.com/pictures/LLX/49680_1_thumb.jpg)
First edition of the scarce offprint of the paper that fully described the discovery of the first hormone, a milestone in the history of physiology and medicine. The discovery was announced in the Proccedings of the Royal Society in Janauary 1902, on 2 pages. The offered item constitutes the first printing of the paper in full, in which the authors described their milestone discovery, which introduced an entirely new field in physiology and medicine, namely the discovery of the FIRST HORMONE, which they named ""Secretin"". A few years later Sterling coined the word 'hormone' (1905) from the Greek 'hormon', meaning to exite or set into motion. Up until Baylis' and Starlings' discovery, it was thought that the glands, here specifically the pancreas, were controlled by the nerves (e.g. Pavlov and others), but Bayliss and Sterling discovered that the intestine was in fact signaling the pancreas, thereby presenting a COMPLETELY NEW MECHANISM involving a new kind of body or substance functioning as a chemical messenger. ""If nerves are the sprinters of biology, Bayliss & Starling had discovered the marathon runners. In doing so, they also founded the science of hormones, called endocrinology"" (Alan Lightman ""The Discoveries"", p. 34 ff). ""With the discovery of hormones, Bayliss & Starling had found the internal command and control centers - and in this, their discovery was much larger than a new communication system. The mechanism of response and control was chemical: atoms and molecules. Now, with hormones, there was a mechanism for a living thing to regulate itself. Furthermore, with hormones, an organism could not only be studied, but also controlled from the outside... Never had the living body come closer to a machine, a self-regulating machine governed not only by physics, but also by chemistry. And not only a machine, but a machine that we humans could willfully control. At the start of the new century, we still have not come to terms with the implications of this idea."" (Alan Lightman).Parkinson ""Breakthroughs"", 1902 B. - Leicester ""Source Book in Chemistry 1900-1950"", pp. 312-13.
"BAYLISS, W.M. (WILLIAM MADDOCK) & ERNEST H. STARLING. - FOUNDING THE SCIENCE OF ENDOCRINOLOGY.
Reference : 49356
(1902)
On the Causation of the so-called 'Peripheral Secretion' of the Pancreas (Preliminary Communication). Received January 22, - Read January 23, 1902.
London, Harrison and Sons, 1902. 8vo. Contemp. full cloth. Top of spine worn down. Lower spine end with a small crack. A collation remark on title-page. A bookmark on inside frontcover, stating that the volume was bound 10/9/02 for City of Manchester. Municipal Technical School. ""Proceedings of the Royal Society"", Vol. 69. VII,501 pp. a. 6 plates. Bayliss & Starling's announcement: pp. 352-353. Internally clean.
This is the first printing, annoucing a milestone discovery which introduced a quite new field in physiology and medicine, the discovery of the FIRST HORMONE, which the discoverers named ""Secretin"". A few years later Sterling coined the word 'hormone' from the Greek 'hormon', meaning to exite or set into motion. Until know it was though that the control of the glands, here the pancreas, was controlled by the nerves (Pavlow and others), but Bayliss and Sterling showed that they have found that the intestine was signalling the pancreas by some COMPLETELY NEW MECHANISM involving a new kind of body or substance functioning as a chemical messenger. ""If nerves are the sprinters of biology, Bayliss & Starling had discovered the marathon runners. In doing so, they also founded the science of hormones, called endocrinology"" (Alan Lightman ""The Discoveries"", p. 34 ff). The announcement, as offered here, was later the same year followed by their larger paper ""The Mechanism of Pancreatic Secretion"" which they published in ""Journal of Physiology (1902)"".""With the discovery of hormones, Bayliss & Starling had found the internal command and control centers - and in this, their discovery was much larger than a new communication system. The mechanism of response and control was chemical: atoms and molecules. Now, with hormones, there was a mechanism for a living thing to regulate itself. Furthermore with hormones, an organism could not only be studied but also controlled from the outside... Never had the living body come closer to a machine, a self-regulating machine governed not only by physics but also chemistry. An not only a machine, but a machine that we human could willfully control. At the start of the new century, we still have not come to terms with the implications of this idea.""(Alan Lightman).Parkinson ""Breakthroughs"", 1902 B.
"BAYLISS, W.M. (WILLIAM MADDOCK) & ERNEST H. STARLING. - THE CHEMICAL MESSINGER.
Reference : 49361
(1904)
The Chemical Regulation of the Secretory process. (Croonian Lecture).
London, Harrison and Sons, 1904. 8vo. Later full buckram. Spine with gilt lettering. In: ""Proceedings of the Royal Society"", Vol. 73. VIII,548 pp. a. 11 plates. (Entire volume offered). Bayliss & Starling's paper: pp. 310-322. A stamp to edges, otherwise clean.
First printing of this paper in which they developed the theory of hormonal control of the internal secretion, a milestone discovery by Bayliss and Starling in 1902, which introduced a quite new field in physiology and medicine, the discovery of the FIRST HORMONE, which the they named ""Secretin"". They here tries to find out how this new body could be decribed chemically, and one of the conclusions were ""It is not precipitated by tannic acid, thus excluding bodies of alkaloid nature as well as di-amido compounds. This evidence, slight thought it is, points to secretin being a body of relatively small molecular weight and not a colloid. It may be compared to the active principle of the suprarenal glands, adrenalin, which has been obtained in a crystallic form and the cemical constitution of which has been approximately determined...""(p. 314-15).Garrison & Morton: 1121.
